Hej!
Är det någon som vill dela med sig av vilka tester som tas i samband med immunologisk utredning hos Dr. D i Aten? Skulle bli jätteglad för en lista på alla tester.
Jag är ny att skriva i tråden men jag har läst en del av era intressanta inlägg. Jag försöker komma fram till vilka skillnader som finns avseende immunologiska tester (för kvinnor) vid olika kliniker i olika länder. Hittills har jag hittat nedanstående exempel på tester:
Gennet i Prag
?COMPLETE REPRODUCTIVE IMMUNOLOGICAL EXAMINATION
? THE PRICE INCLUDES:
? Basic parameters of antibody immunity - concentration of IgA, IgG, IgM and IgE antibodies
? Basic parameters of cellular immunity - number of T, B, NK cells including Th, Tc, NKT
subpopulations
? Regulatory T cells - number of cells providing tolerogenic immune response (Treg)
? Pro-inflammatory markers ? CRP
? Complement examination - C3, C4, MBP
? Thyroid autoimmune disorders - thyroid perixodiase antibodies (TPO)
? Celiac disease - antibodies against tissue transglutaminase (tTG) IgA
? Autoimmune disease - antinuclear antibodies (ANA), ENA type test (SSA, SSB, Sm, Sm/RNP, Jo1,
Scl-70), anti-nucleosome antibodies
? Antiphospholipids - antibodies against Annexin V, prothrombin, APLA profile (cardiolipin, beta-2-
glycoprotein, phosphatidylserine, phosphatidylinositol, phosphatidyl acid)
? Block of reproduction tests - anti-ovarian, anti-zona pellucida and anti-sperm antibodies in the serum
? Egg maturation - AMH
? IgE seminal fluid
? Cellular testing:
? Examination of NK cells activity (after stimulation with mitogen, sperm* and trophoblast)
? Examination of embryotoxic/embryoprotective cytokines (after stimulation with
mitogen, sperm* and trophoblast)?
The Fertility & Gynaecology Academy i London
?Immune Testing
To establish any issues that may be preventing a successful IVF treatment, we carry out a comprehensive series of tests which check different aspects of your immune system. At The Fertility & Gynaecology Academy we feel it is important that you understand the different tests carried out.
Once we have identified the problem using the series of tests below, we can provide relevant immune therapy ? for example Intralipids or IVIg infusions, Corticosteroids, Clexane, Progesterones and Lymphocyte Immune Therapy (LIT).
Natural Killer (NK) Cell Cytoxicity Assay And Immunophenotype
This test first measures the killing power of the NK cells in your blood. Secondly, it looks at the numbers of different types of white cells in your blood. We look at these specific types of cells because elevated concentrations of them have been shown to be associated with various fertility problems. For example:
TH1:TH2 Cytokine Ratio
Cytokines are chemical messengers in the blood. High levels of the TH1 pro-inflammatory cytokine ? TNF-alpha, in particular ? have been shown to be associated with reduced egg quality, implantation failure and miscarriage.
Leukocyte Antibody Detection (LAD)
This test requires a sample of blood from both the prospective mother (or gestational carrier) and another person (usually the prospective father). It measures the levels of blocking antibodies in the prospective mother?s blood to samples of white cells from the prospective father. Low levels of blocking antibodies are associated with higher rates of miscarriage and implantation failure.
HLA-DQ Alpha Testing
The test determines which DQ Alpha markers your body cells carry. To achieve the best results, this test is usually carried out for both the prospective mother and the prospective father. This is because where the prospective mother and father carry very similar markers, there is an increased chance that their embryos may carry identical markers to the mother. In that case, there may be an increased rate of implantation failure and/or miscarriage. This can be due to an increased immune response which may become more aggressive with each successive attempted implantation of a DQ Alpha matching embryo.
Testing By Uterine Biopsy
This test requires a small sample taken from the lining of the uterus, ideally before your period is due. The sample can be taken at our clinic or, in some cases, taken elsewhere and forwarded to us. Samples are analysed for excessive levels of uterine NK cells, for adequate levels of FoxP3 +ve T-regulatory cells and for the health and development of the uterine lining.
Tests For Inherited Thrombophilia: Factor II & V and MTHFR Gene Mutation
These are genetic conditions, some of which are very common. All thrombophilia (?sticky blood conditions?) can cause problems for maintaining an adequate blood supply to the uterine lining and to the growing placenta, which results in increased rates of implantation failure and miscarriage.
Tests For Acquired Thrombophilia/Antiphospholipid Antibodies
Additional tests for thrombophilia may be available to you via your GP, but if not, can be arranged through The Fertility & Gynaecology Academy.
Screening For Autoimmune Factors
Undiagnosed autoimmune disease may be associated with increased risk of pregnancy failure, potentially due to elevated TNF-alpha ratios. A screening panel will commonly include tests for Antinuclear Antibodies (ANA), Anti-Histone and ds-DNA antibodies. These tests may be available to you via your GP, but if not, can be arranged through The Fertility & Gynaecology Academy.
Killer-Cell Immunoglobulin-like Receptors (KIRs)
KIRs are a family of protein receptors on the surface of NK cells, mostly inhibitory but some activating. There is an increased risk of implantation failure and/or miscarriage if particular members of the activating KIRs are missing. The risk can be reduced by using G-CSF (Neupogen).?
Serum IVF Centre i Aten
?Immunological Treatments
Natural Killers
In some women, the immune defenses may be overactive leading to poor tolerance of the embryo and a direct attack on the fetal cells by maternal uNKs.
Thrombophilias
Some mothers have a condition called thrombophilia (excessive blood clotting) caused by a variety of genetic or autoimmune reasons.
Systemic Inflammation
In some men and women, levels of inflammatory cytokines like TNFalpha can be very high, which leads to reduced egg and sperm quality and to a more hostile uterus.
Alloimune Problems
In some women, we find a failure to make antibodies capable of recognizing embryonic cells?
Känns svårt att veta vilka tester som är viktigast när man inte är medicinskt utbildad 
Delar säkert denna känsla med många av er, tror jag.
Har inte haft några symptom alls (mycket molvärk och muntorr v.4-5, men inget alls sedan dess), inget illamående, inga ömma bröst, ingen extrem trötthet (kan ju bero på kortisonet).
