vet någon av er någonting om Dexametason? Dr Beer skriver om denn ai boken oc jag har spannat in det här:
http://74.125.77.132/search?q=cache:Ui3nofnO6cQJ:www.fertilethoughts.com/forums/immune-issues/564964-dex-vs-prednisone.html+dexametason+vs+prednison+trudnoca&cd=1&hl=sv&ct=clnk&gl=se
Oh, & also some info from the Dr.Beer forums site at yahoo:
9. Question:
I will explain my situation and maybe Dr Beer can tell us the reasoning behind the different prescriptions? I am Category 1, 2, 3, 4, 5. I cannot do IVIg (IgA deficiency) and chose not to take Humira. I was on dexamethasone 1mg daily while trying to conceive from CD6. I got pregnant and continued the dexamethasone. Around 5 weeks we increased to twice daily because of my history of subchorionic hemorrhage. At 6 weeks US there was a possible hemorrhage, and Dr Beer switched me to 10mg prednisone twice daily - which I am still on, and the subchorioninc hemorrhage has disappeared at 9 weeks. So something has worked! My question: why the switch from dexamethasone to prednisone when all the literature says dexamethasone and prednisone are the same?
Answer: Dexamethasone and prednisone are not the same. Dexamethasone, not prednisone can prevent cell division of NK cells. Both calm inflammation produced by category 2 qand 3 immune problems. Prednisone can in my experience be given for a longer period during a pregnancy and data shows that women who take extra calcium do well without any bone side effects. With doses of over 20 mg a day prednisone increases the risk of gestational diabetes and screening for this condition. is necessary.
Question: There must be some differences? Just curious about it - and alot of other women are too, from the amount of discussion on it.
Answer: There are differences. I like dexamethasone better pre pregnancy and during early pregnancy because it also suppresses NK cells and reduces the need for Humira and IVIG. Your case is an example. In patients like you I find the risk of problems returning between 18 and 22 weeks and this involves slowing of the growth of the baby and shrinking of the amniotic fluid. This is why I do frequent ultrasound examinations in all of my patients taking immune medications.
Alan E Beer, MD
10. Question:
Is the use of the dexamethasone continued for the same length as the prednisone?
Answer: No prednisone in my patients is given for a longer period of time.
Question: Dr. Coulam mentioned that dexamethasone could have the side effect
of "runting" on the baby (her words).
Answer: Runting as I have studied it is cause by an aggressive immune attack in the mother against the placenta. Runting is prevented by proper immune treatment of the type discussed above. I was the first ever to describe runt disease and certainly can put your mind at ease that none of the medications I give cause runting, but the autoimmunity routinely causes runting if not properly treated.
Question: Is Dr Beer concerned about that at all?
Answer: Of course I described this condition to the medical world many years ago.
Question: And also, does he normally keep his patients on it throughout
pregnancy, or just into/through the first trimester?
Answer: See the answers to the questions above about length of treatment.
Alan E Beer, MD
11. Question:
Something else on dexamethasone, when trying to conceive using dexamethasone, if the first month
doesn't work (we don't get pregnant), do we stop the dexamethasone from CD1 to CD6 and then start up again?
Answer: Yes, Stop it with the start of menstruation (with a negative pregnancy test) and start it again on cycle day 6.
Question: So there's no phasing out, just drop for 5 days and start again, correct?
Answer: Yes this is what I recommend and with these short bursts of use there is no reason to wean off the medication.
Alan E Beer, MD
Tänkte väl testa något halvår eller så, men får se hur det känns längre fram...